The song reached number three on the Billboard Hot 100 chart and is Train's highest-charting song to date. As of September 21, 2012, it had sold over 6 million digital copies in the US. It was the top-selling song on the iTunes Store in 2010, and the second overall best-selling song in the US in 2010. It is also the band's most commercially successful single to date, reaching number one in 16 countries. The single received a 6x platinum certification by the Recording Industry Association of America (RIAA) on September 21, 2012, signifying sales of over 6 million copies. The live iTunes version of "Hey, Soul Sister" garnered a Grammy Award for Train at the 53rd Annual Grammy Awards. The song was not eligible for any Grammy Award in the General Field.